P02787
TRFE_HUMANTF
Serotransferrin
血清转铁蛋白
Homo sapiensTaxon: 9606
3D-structureDirect protein sequencingDisease variantDisulfide bondGlycoproteinIon transportIronIron transportMetal-bindingMethylationPhosphoproteinProteomics identification+5
序列长度
698
氨基酸
分子量
77.1 kDa
理论值
实验结构
50
PDB 条目
相关疾病
1
已记录
功能描述
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation
(Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use
(Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use
转铁蛋白是铁结合转运蛋白，可以结合两个 Fe(3+) 离子，并与阴离子（通常是碳酸氢根）结合。 它负责将铁从吸收和血红素降解部位运输到储存和利用部位。 血清转铁蛋白还可能在刺激细胞增殖方面发挥进一步作用
（微生物感染）作为奈瑟菌属物种的铁源，奈瑟菌属物种捕获蛋白质并提取铁供自己使用
（微生物感染）作为寄生虫 T.brucei（菌株 427）的铁源，该寄生虫通过其自身的转铁蛋白受体 ESAG6:ESAG7 捕获 TF 并提取铁供自己使用
您所阅读的中文介绍为AI翻译机制自动翻译，并未经过人工审核，如有错漏，请以英文原文为准！
定位与分布
组织特异性
Expressed by the liver and secreted in plasma
相关疾病
Atransferrinemia
A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia.
氨基酸序列
MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPC ADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRD
FASTA 格式 · 698 个氨基酸 · 分子量 77.1 kDa