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Catalase structure
P04040
CATA_HUMAN
CAT

Catalase

过氧化氢酶

Homo sapiensTaxon: 9606

3D-structureAcetylationDirect protein sequencingHemeHydrogen peroxideIronMetal-bindingMitogenNADPOxidoreductasePeroxidasePeroxisome+3
序列长度

527

氨基酸

分子量

59.8 kDa

理论值

实验结构

16

PDB 条目

相关疾病

1

已记录

功能描述

Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)
催化过氧化物酶体氧化酶产生的过氧化氢 (H(2)O(2)) 降解为水和氧气，从而保护细胞免受过氧化氢的毒性作用 (PubMed:7882369)。 促进细胞生长，包括 T 细胞、B 细胞、骨髓性白血病细胞、黑色素瘤细胞、肥大细胞瘤细胞以及正常和转化的成纤维细胞 (PubMed:7882369)
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相关疾病

Acatalasemia

A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.

氨基酸序列

MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ

FASTA 格式 · 527 个氨基酸 · 分子量 59.8 kDa