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Vimentin structure
P08670
VIME_HUMAN
VIM

Vimentin

Homo sapiensTaxon: 9606

3D-structureAcetylationCataractCell membraneCell projectionCoiled coilCytoplasmCytoskeletonDirect protein sequencingDisease variantGlycoproteinHost-virus interaction+9
序列长度

466

氨基酸

分子量

53.7 kDa

理论值

实验结构

26

PDB 条目

相关疾病

1

已记录

功能描述

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity) Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2
波形蛋白是在各种非上皮细胞，尤其是间充质细胞中发现的 III 类中间丝。 波形蛋白附着在细胞核、内质网和线粒体的侧面或末端。 在细胞迁移前沿的细胞定向运动、方向、细胞片组织和高尔基复合体极化中发挥作用（通过相似性）。 保护 SCRIB 免受蛋白酶体降解，并促进其以细胞接触介导的方式定位到中间丝（通过相似性）。 可以通过 DSP 介导的募集到生长尖端来促进轴突生长和运动纤维修复（通过相似性） 参与 LARP6 稳定 CO1A1 和 CO1A2 的 I 型胶原蛋白 mRNA
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定位与分布

组织特异性

Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines

相关疾病

Cataract 30, multiple types

An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.

氨基酸序列

MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV
YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK
VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE

FASTA 格式 · 466 个氨基酸 · 分子量 53.7 kDa