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Small ribosomal subunit protein uS2 structure
P08865
RSSA_HUMAN
RPSA

Small ribosomal subunit protein uS2

Homo sapiensTaxon: 9606

3D-structureAcetylationCell membraneCytoplasmDirect protein sequencingDisease variantHost cell receptor for virus entryHost-virus interactionIsopeptide bondMembraneNucleusPhosphoprotein+7
序列长度

295

氨基酸

分子量

32.9 kDa

理论值

实验结构

50

PDB 条目

相关疾病

1

已记录

功能描述

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9 (Microbial infection) Acts as a receptor for the Dengue virus (Microbial infection) Acts as a receptor for the Sindbis virus (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus (Microbial infection) Acts as a receptor for the pathogenic prion protein (Microbial infection) Acts as a receptor for bacteria

相关疾病

Asplenia, isolated congenital

A rare primary immunodeficiency and life-threatening condition, often presenting with pneumococcal sepsis. Most affected individuals die of severe bacterial infections in early childhood. Isolated asplenia is distinct from asplenia associated with other complex visceral defects, notably heterotaxy syndromes such as Ivemark syndrome.

氨基酸序列

MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR
LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR
EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA

FASTA 格式 · 295 个氨基酸 · 分子量 32.9 kDa