Guanine nucleotide-binding protein G(o) subunit alpha

Homo sapiensTaxon: 9606

3D-structureADP-ribosylationAlternative splicingCell membraneDisease variantEpilepsyGTP-bindingHydrolaseLipoproteinMagnesiumMembraneMetal-binding+6

序列长度

354

氨基酸

分子量

40.1 kDa

理论值

实验结构

PDB 条目

功能描述

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity)

鸟嘌呤核苷酸结合蛋白 (G 蛋白) 在众多信号级联中充当 G 蛋白偶联受体 (GPCR) 下游的转导子 (PubMed:29925951、PubMed:33408414)。 α 链包含鸟嘌呤核苷酸结合位点，并在活性、GTP 结合状态和非活性、GDP 结合状态之间交替（通过相似性）。激活的 GPCR 发出的信号会促进 GDP 释放和 GTP 结合（通过相似性）。 α 亚基具有低 GTP 酶活性，可将结合的 GTP 转化为 GDP，从而终止信号（通过相似性）。 GDP 释放和 GTP 水解均受众多调节蛋白的调节（通过相似性）。信号传导通过效应蛋白介导，例如腺苷酸环化酶（通过相似性）。抑制腺苷酸环化酶活性，导致细胞内 cAMP 水平降低（通过相似性）

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氨基酸序列

MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDG
FSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPF
SAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRV
KTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET

FASTA 格式 · 354 个氨基酸 · 分子量 40.1 kDa