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Heme oxygenase 1 structure
P09601
HMOX1_HUMAN
HMOX1

Heme oxygenase 1

Homo sapiensTaxon: 9606

3D-structureApoptosisEndoplasmic reticulumHemeHost-virus interactionIronMembraneMetal-bindingOxidoreductasePhosphoproteinProteomics identificationReference proteome+2
序列长度

288

氨基酸

分子量

32.8 kDa

理论值

实验结构

26

PDB 条目

相关疾病

1

已记录

功能描述

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707) (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron

定位与分布

组织特异性

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)

相关疾病

Heme oxygenase 1 deficiency

A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.

氨基酸序列

MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA

FASTA 格式 · 288 个氨基酸 · 分子量 32.8 kDa